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KMID : 0624620110440080517
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BMB Reports
2011 Volume.44 No. 8 p.517 ~ p.522
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Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death
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Park So-Jung
Shin Ji-Hyun
Kang Hee
Hwang Jung-Jin
Cho Dong-Hyung
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Abstract
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Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death.
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KEYWORD
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Apoptosis, Autophagy, Fission, Mitochondria dynamics, Niclosamide
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